ChloroquineV1, Main, Exploration, bibRecord, 002884

Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins

Identifieur interne : 002884 ( Main/Exploration ); précédent : 002883; suivant : 002885

Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins

Auteurs : D. J. A Crommelin [Pays-Bas] ; T. Daemen [Pays-Bas] ; G. L Scherphof [Pays-Bas] ; M. H Vingerhoeds [Pays-Bas] ; J. L. M Heeremans [Pays-Bas] ; C. Kluft [Pays-Bas] ; G. Storm [Pays-Bas]

Source :

Journal of Controlled Release [ 0168-3659 ] ; 1997.

RBID : ISTEX:009AE18C427F3F84A8B9C01676A0EC7748699601

English descriptors

Teeft :
- Acta, Biochim, Biophys, Blood cells, Blood circulation, Boca raton, Carcinoma, Crommelin, Daemen, Doxorubicin, Endothelial cells, Enzyme prodrug therapy, Groningen, Heeremans, Homing, Homing device, Immunoliposomes, Immunomodulators, Intravenous administration, Kluft, Larger cells, Liposomal, Liposomal delivery, Liposomal doxorubicin, Liposomal muramyl dipeptide, Liposome, Liver macrophage population, Liver macrophages, Liver metastases, Macrophage, Macrophage activation, Macrophage population, Marcel dekker, Metastasis, Monoclonal antibody, Mononuclear phagocyte system, Muramyl, Murine liver metastases, Ovarian carcinoma cells, Peptide, Peritoneal, Peritoneal cavity, Phagocytic, Phagocytic capacity, Physiological chemistry, Plasminogen, Plasminogen activator, Prodrug, Release kinetics, Scherphof, Target cell, Target cells, Target site, Target sites, Therapeutic effect, Tumor cells, Tumor challenge, Tumor cytotoxicity, Tumoricidal, Tumoricidal activity, Tumoricidal response, Unconjugated liposomes, Utrecht, Utrecht university, Vingerhoeds.

Abstract

Abstract: Several approaches are presented that have been developed for the liposomal delivery of peptides and proteins. For a rational design of targeted liposomes, the anatomical and physiological constraints with respect to the distribution of liposomes in the body have to be taken into account. Target sites that offer exciting opportunities are located in the blood compartments (e.g. thrombi, endothelium), in the liver (e.g. macrophages), in the peritoneal cavity (e.g. tumor cells), or in diseased tissues (e.g. inflammations or tumors). Examples of ongoing liposome-related research in our institutes are discussed.

Url:

https://api.istex.fr/ark:/67375/6H6-8903H9GW-Q/fulltext.pdf

DOI: 10.1016/S0168-3659(96)01583-0

Affiliations:

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Le document en format XML

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<wicri:regionArea>Gaubius Laboratory, TNO-PG, P.O. Box 430, 2300 AK, Leiden</wicri:regionArea>
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<term>Blood cells</term>
<term>Blood circulation</term>
<term>Boca raton</term>
<term>Carcinoma</term>
<term>Crommelin</term>
<term>Daemen</term>
<term>Doxorubicin</term>
<term>Endothelial cells</term>
<term>Enzyme prodrug therapy</term>
<term>Groningen</term>
<term>Heeremans</term>
<term>Homing</term>
<term>Homing device</term>
<term>Immunoliposomes</term>
<term>Immunomodulators</term>
<term>Intravenous administration</term>
<term>Kluft</term>
<term>Larger cells</term>
<term>Liposomal</term>
<term>Liposomal delivery</term>
<term>Liposomal doxorubicin</term>
<term>Liposomal muramyl dipeptide</term>
<term>Liposome</term>
<term>Liver macrophage population</term>
<term>Liver macrophages</term>
<term>Liver metastases</term>
<term>Macrophage</term>
<term>Macrophage activation</term>
<term>Macrophage population</term>
<term>Marcel dekker</term>
<term>Metastasis</term>
<term>Monoclonal antibody</term>
<term>Mononuclear phagocyte system</term>
<term>Muramyl</term>
<term>Murine liver metastases</term>
<term>Ovarian carcinoma cells</term>
<term>Peptide</term>
<term>Peritoneal</term>
<term>Peritoneal cavity</term>
<term>Phagocytic</term>
<term>Phagocytic capacity</term>
<term>Physiological chemistry</term>
<term>Plasminogen</term>
<term>Plasminogen activator</term>
<term>Prodrug</term>
<term>Release kinetics</term>
<term>Scherphof</term>
<term>Target cell</term>
<term>Target cells</term>
<term>Target site</term>
<term>Target sites</term>
<term>Therapeutic effect</term>
<term>Tumor cells</term>
<term>Tumor challenge</term>
<term>Tumor cytotoxicity</term>
<term>Tumoricidal</term>
<term>Tumoricidal activity</term>
<term>Tumoricidal response</term>
<term>Unconjugated liposomes</term>
<term>Utrecht</term>
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<front><div type="abstract" xml:lang="en">Abstract: Several approaches are presented that have been developed for the liposomal delivery of peptides and proteins. For a rational design of targeted liposomes, the anatomical and physiological constraints with respect to the distribution of liposomes in the body have to be taken into account. Target sites that offer exciting opportunities are located in the blood compartments (e.g. thrombi, endothelium), in the liver (e.g. macrophages), in the peritoneal cavity (e.g. tumor cells), or in diseased tissues (e.g. inflammations or tumors). Examples of ongoing liposome-related research in our institutes are discussed.</div>
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Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins

Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri